In the episode where they go to the Bedrock Country Club, look a Betty's dress when they walk in. Then, when they are talking, it changes. Then, when Fred and Barney get in the fight, it changes again. It's pretty strange.
what is strange is why Mr. Slate in the earlier episodes is a short guy with brown hair, kinda looks like Mr. Sproket from the Jetsons. Then in the later episodes he is the tall bald guy....what's with that
Fred's boss changed in both appearance and name a few times, but eventually became the "Mr. Slate" we all know and love(?). (Maybe the company got bought a few times?) Also, Wilma's maiden name was originally "Pebble", but it was changed later to "Slaggoople". (I think it was so people wouldn't confuse it with Pebbles.) Oh, and I know it was Pebble first because in the spinoff "Flinstone Kids", Wilma's last name is Slaggoople. Also, I think the address of Fred's house is different every time they mention it.
Now I'm going over to comment on the "Talking Dino slip up", which is similar to these mid-series changes.
It's not exactly a slip-up, but did you notice that the opening theme song where it says,'...we'll have a gay-o time...' was later changed to,'...we'll have a great-o time...'? Time changes meanings, eh?